克罗米酚对男性低促性腺素持续性减退症有效

波士顿（路透社健康版）1年初四日报道：据撰写在12年初出版的《分娩与不孕》杂志的一项统计数据宣称克罗米醇对部分较低促性腺素性功能减退的成年人症状十分困难。来自伯明翰阿拉巴马大学的该统计数据的第一著者Scott J. WhittenClark在放弃路透通讯社采访时时说：“病症或获得性HH症状在放弃侵犯性更大和更为较贵的病人（例如注射促性腺激素类）前顺利进行4个年初的克罗米醇值得一提的是病人是十分困难的。”WhittenClark和同事研究了克罗米醇对10名HH成年人症状（HH是导致成年人不孕的少见因素）是否有效。统计数据称克罗米醇病人1年后，4名卡尔曼(氏)遗传性症状中只有一名症状的受精卵溶解度增加而全输卵管功能减退症症状的受精卵缺乏症状均很难获得缓解。相反，该统计数据宣称3名成年发病的病症HH成年人症状经过3个年初克罗米醇的病人受精卵溶解度有了明显增加。迄今为止该组症状已有两名恢复了身体健康。WhittenClark时说：“除非对克罗米醇病人很难反应，我们会因为抗抑郁药停止对症状使用该口服。”最后著者阐释时说：“因为条件有限，对HH症状促性腺激素类口服和克罗米醇的随机研究很难顺利进行，然而利用多系列的严格选择标准对症状顺利进行分级可能帮助进一步实验者克罗米醇恢复成年人较低身体健康的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色幻想

编辑： 张靖